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Identification of human placental leucine aminopeptidase as oxytocinase

โœ Scribed by Masafumi Tsujimoto; Shigehiko Mizutani; Hideki Adachi; Masami Kimura; Hiroshi Nakazato; Yutaka Tomoda


Book ID
115709019
Publisher
Elsevier Science
Year
1992
Tongue
English
Weight
734 KB
Volume
292
Category
Article
ISSN
0003-9861

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Human pregnancy serum and placenta have the ability to degrade uterotonic peptide oxytocin (OT). Placental leucine aminopeptidase (P-LAP), which is also called cystine aminopeptidase, is the only membrane aminopeptidase known to functionally degrade OT as oxytocinase (OTase). P-LAP/OTase hydrolyzes