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Placental leucine aminopeptidase/oxytocinase in maternal serum and placenta during normal pregnancy

✍ Scribed by Noboru Yamahara; Seiji Nomura; Takanobu Suzuki; Atsuo Itakura; Mitsuaki Ito; Tomomitsu Okamoto; Masafumi Tsujimoto; Hiroshi Nakazato; Shigehiko Mizutani


Book ID
117172237
Publisher
Elsevier Science
Year
2000
Tongue
English
Weight
789 KB
Volume
66
Category
Article
ISSN
0024-3205

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Human pregnancy serum and placenta have the ability to degrade uterotonic peptide oxytocin (OT). Placental leucine aminopeptidase (P-LAP), which is also called cystine aminopeptidase, is the only membrane aminopeptidase known to functionally degrade OT as oxytocinase (OTase). P-LAP/OTase hydrolyzes