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AP-2 and Ikaros Regulate Transcription of Human Placental Leucine Aminopeptidase/Oxytocinase Gene

โœ Scribed by Tomomi Ito; Seiji Nomura; Mayumi Okada; Yoshinari Katsumata; Fumitaka Kikkawa; Tomohiro Rogi; Masafumi Tsujimoto; Shigehiko Mizutani


Book ID
115589363
Publisher
Elsevier Science
Year
2002
Tongue
English
Weight
202 KB
Volume
290
Category
Article
ISSN
0006-291X

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Gene regulation and physiological functi
โœ Seiji Nomura; Tomomi Ito; Eiko Yamamoto; Seiji Sumigama; Akira Iwase; Mayumi Oka ๐Ÿ“‚ Article ๐Ÿ“… 2005 ๐Ÿ› Elsevier Science ๐ŸŒ English โš– 309 KB

Human pregnancy serum and placenta have the ability to degrade uterotonic peptide oxytocin (OT). Placental leucine aminopeptidase (P-LAP), which is also called cystine aminopeptidase, is the only membrane aminopeptidase known to functionally degrade OT as oxytocinase (OTase). P-LAP/OTase hydrolyzes