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Identification of HLA-class-II-restricted epitopes of autoantigens in transgenic mice

✍ Scribed by Roshini S Abraham; Chella S David

Publisher: Elsevier Science
Year: 2000
Tongue: English
Weight: 109 KB
Volume: 12
Category: Article
ISSN: 0952-7915
DOI: 10.1016/s0952-7915(99)00060-6

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✦ Synopsis

The past year has seen a spate of research in the use of HLA transgenic mice in the identification of self antigens associated with autoimmunity. Dominant T cell determinants -and, in a few cases, B cell determinants -have been characterized in the context of disease-predisposing HLA DR and DQ genes for at least three prominent and devastating autoimmune diseases: rheumatoid arthritis, multiple sclerosis and insulindependent diabetes mellitus.

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