Peptide immunisation of HLA-DR–transgenic mice permits the identification of a novel HLA-DRβ1*0101– and HLA-DRβ1*0401–restricted epitope from p53

Identification of an HLA-DR-restricted p

Identification of an HLA-DR-restricted peptide epitope with a promiscuous binding pattern derived from the cancer testis antigen HOM-MEL-40/SSX2

✍ Frank Neumann; Claudia Wagner; Stefan Stevanovic; Boris Kubuschok; Claudia Schor 📂 Article 📅 2004 🏛 John Wiley and Sons 🌐 French ⚖ 129 KB

## Abstract The __SSX2__ gene encodes the tumor‐specific antigen HOM‐MEL‐40/SSX2 expressed in a broad spectrum of tumors of different origin, against which humoral and CD8^+^ T‐cell‐mediated MHC‐I‐restricted responses have been demonstrated. Searching for promiscuous MHC‐II‐restricted peptides that