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Identification of Diarylsulfone Sulfonamides as Secreted Frizzled Related Protein-1 (sFRP-1) Inhibitors

โœ Scribed by Gopalsamy, Ariamala; Shi, Mengxiao; Stauffer, Barbara; Bahat, Ramesh; Billiard, Julia; Ponce-de-Leon, Helga; Seestaller-Wehr, Laura; Fukayama, Shoichi; Mangine, Annamarie; Moran, Robert; Krishnamurthy, Girija; Bodine, Peter


Book ID
126837957
Publisher
American Chemical Society
Year
2008
Tongue
English
Weight
82 KB
Volume
51
Category
Article
ISSN
0022-2623

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## Abstract ## BACKGROUND. The secreted frizzledโ€related protein 1 gene (__SFRP1__) encodes a Wnt/ฮฒโ€catenin signaling antagonist and frequently is inactivated by promoter methylation in many tumors. However, the role of __SFRP1__ in hepatocellular carcinoma (HCC) is not clear. Therefore, the autho