Identification of aberrant promoter methylation of EDNRB gene in esophageal squamous cell carcinoma
β Scribed by B.-J. Zhao; D.-G. Sun; M. Zhang; S.-N. Tan; X. Ma
- Book ID
- 108982109
- Publisher
- John Wiley and Sons
- Year
- 2009
- Tongue
- English
- Weight
- 235 KB
- Volume
- 22
- Category
- Article
- ISSN
- 1120-8694
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## Abstract To identify the epigenetic changes in nasopharyngeal carcinoma (NPC), we performed methylationβsensitive restriction fingerprinting (MSRF) analysis on NPC cell lines and xenografts. A 190 bp sequence methylated in NPC tumors was isolated and showed high homology to the 5β² CpG island of
## Abstract Previous studies on esophageal squamous cell carcinoma (ESCC) indicated that it contains much dysregulation of microRNAs (miRNAs). DNA hypermethylation in the miRNA 5β² regulatory region is a mechanism that can account for the downregulation of miRNA in tumors (Esteller, N Engl J Med 200