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Identification of a peptide blocking vascular endothelial growth factor (VEGF)-mediated angiogenesis

✍ Scribed by Binetruy-Tournaire, R.

Book ID
111747815
Publisher
Nature Publishing Group
Year
2000
Tongue
English
Weight
265 KB
Volume
19
Category
Article
ISSN
0261-4189

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## Abstract VEGF and TGF‐β1 induce angiogenesis but have opposing effects on endothelial cells. VEGF protects endothelial cells from apoptosis; TGF‐β1 induces apoptosis. We have previously shown that VEGF/VEGF receptor‐2 (VEGFR2) signaling mediates TGF‐β1 induction of apoptosis. This finding raised