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Angiogenesis mediated by metabolites is dependent on vascular endothelial growth factor (VEGF)

✍ Scribed by P.A. Burns; D.J. Wilson

Book ID
111554322
Publisher
Springer
Year
2003
Tongue
English
Weight
538 KB
Volume
6
Category
Article
ISSN
0969-6970

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## Abstract VEGF and TGF‐β1 induce angiogenesis but have opposing effects on endothelial cells. VEGF protects endothelial cells from apoptosis; TGF‐β1 induces apoptosis. We have previously shown that VEGF/VEGF receptor‐2 (VEGFR2) signaling mediates TGF‐β1 induction of apoptosis. This finding raised