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Vascular Endothelial Growth Factor (VEGF)-Induced Retinal Vascular Permeability Is Mediated by Intercellular Adhesion Molecule-1 (ICAM-1)

✍ Scribed by Kazuaki Miyamoto; Samer Khosrof; Sven-Erik Bursell; Yasufumi Moromizato; Lloyd Paul Aiello; Yuichiro Ogura; Anthony P. Adamis

Book ID
117022505
Publisher
American Society for Investigative Pathology
Year
2000
Tongue
English
Weight
535 KB
Volume
156
Category
Article
ISSN
0002-9440

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## Abstract VEGF and TGF‐β1 induce angiogenesis but have opposing effects on endothelial cells. VEGF protects endothelial cells from apoptosis; TGF‐β1 induces apoptosis. We have previously shown that VEGF/VEGF receptor‐2 (VEGFR2) signaling mediates TGF‐β1 induction of apoptosis. This finding raised