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Insulin-like growth factor binding protein-7 (IGFBP7) blocks vascular endothelial cell growth factor (VEGF)-induced angiogenesis in human vascular endothelial cells

โœ Scribed by Kazuhiro Tamura; Keisuke Hashimoto; Kenta Suzuki; Mikihiro Yoshie; Masahiko Kutsukake; Toshihiro Sakurai


Book ID
113588101
Publisher
Elsevier Science
Year
2009
Tongue
English
Weight
702 KB
Volume
610
Category
Article
ISSN
0014-2999

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Vascular endothelial growth factor (VECF) is a 45kDa secreted peptide that has potent mitogenic activity specific for endothelial cells in vitro and the ability to induce a strong angiogenic response in vivo. In the present study, 24 h treatment with VEGF resulted in a stimulation of expression of t