Identification of a Nuclear Receptor for
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Makishima, M.
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Article
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1999
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American Association for the Advancement of Scienc
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English
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Bile acids are essential for the solubilization and transport of dietary lipids and are the major products of cholesterol catabolism. Results presented here show that bile acids are physiological ligands for the farnesoid X receptor (FXR), an orphan nuclear receptor. When bound to bile acids, FXR re