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Bile Acids: Natural Ligands for an Orphan Nuclear Receptor

✍ Scribed by Parks, D. J.

Book ID: 121161068
Publisher: American Association for the Advancement of Science
Year: 1999
Tongue: English
Weight: 189 KB
Volume: 284
Category: Article
ISSN: 0036-8075
DOI: 10.1126/science.284.5418.1365

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Bile acids are essential for the solubilization and transport of dietary lipids and are the major products of cholesterol catabolism. Results presented here show that bile acids are physiological ligands for the farnesoid X receptor (FXR), an orphan nuclear receptor. When bound to bile acids, FXR re