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The Orphan Nuclear Receptor, shp, Mediates Bile Acid-Induced Inhibition of the Rat Bile Acid Transporter, ntcp

โœ Scribed by Lee A. Denson; Ekkehard Sturm; Wihelma Echevarria; Tracy L. Zimmerman; Makoto Makishima; David J. Mangelsdorf; Saul J. Karpen


Book ID
119756275
Publisher
Elsevier Science
Year
2001
Tongue
English
Weight
289 KB
Volume
121
Category
Article
ISSN
0016-5085

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Chemical genomics: Functional analysis o
โœ Timothy M. Willson; Stacey A. Jones; John T. Moore; Steven A. Kliewer ๐Ÿ“‚ Article ๐Ÿ“… 2001 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 216 KB

## Abstract Chemical genomics is the name we have given to the analysis of gene function through use of small molecule chemical tools. Orphan nuclear receptors are ideally suited to this technique of functional analysis, since their activity as transcription factors is regulated by small hydrophobi