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Bile acid regulates c-Jun expression through the orphan nuclear receptor SHP induction in gastric cells

✍ Scribed by Won Il Park; Min Jung Park; Jin Kwang An; Yung Hyun Choi; Hye Young Kim; JaeHun Cheong; Ung Suk Yang


Book ID
116296466
Publisher
Elsevier Science
Year
2008
Tongue
English
Weight
248 KB
Volume
369
Category
Article
ISSN
0006-291X

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Gpbar1 (TGR5), a membrane-bound bile acid receptor, is well known for its roles in regulation of energy homeostasis and glucose metabolism. TGR5 also displays strong attenuation of macrophage reactivity in vitro, but the physiological roles of TGR5 in inflammatory response, and its mechanism, is unk