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Identification of a nonpeptide cyclic urea inhibitor of HIV protease using in silico molecular docking

✍ Scribed by Mohsen Yazdani; Mahdi Masomi

Book ID
118431487
Publisher
Elsevier Science
Year
2011
Tongue
English
Weight
122 KB
Volume
44
Category
Article
ISSN
0009-9120

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## Abstract The pharmacokinetics of a series of novel cyclic, non‐peptide inhibitors of HIV protease were studied in rats or dogs after intravenous and oral administration. Six symmetrically substituted cyclic urea compounds (XK234, XM311, XM320, XM321, XM323, and XM412), which effectively inhibite