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Identification of a new selective dopamine D4 receptor ligand

✍ Scribed by Sampson, Dinithia; Zhu, Xue Y.; Eyunni, Suresh V.K.; Etukala, Jagan R.; Ofori, Edward; Bricker, Barbara; Lamango, Nazarius S.; Setola, Vincent; Roth, Bryan L.; Ablordeppey, Seth Y.


Book ID
121847081
Publisher
Elsevier Science
Year
2014
Tongue
English
Weight
937 KB
Volume
22
Category
Article
ISSN
0968-0896

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The identification of a novel dopamine receptor subtype, referred to as the D4 receptor, which binds the atypical antipsychotic drug clozapine with high potency, has led to the initiation of a drug discovery program that aims to find novel inhibitors of this receptor subtype. A selective screening s