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Raclopride, a new selective ligand for the dopamine-D2 receptors

✍ Scribed by Hall, HÃ¥kan; Köhler, Christer; Gawell, Lars; Farde, Lars; Sedvall, Göran

Book ID
120037707
Publisher
Elsevier Science
Year
1988
Tongue
English
Weight
661 KB
Volume
12
Category
Article
ISSN
0278-5846

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The selective dopamine D2receptor antagonist raclopride discriminates between dopamine-mediated motor functions
✍ Sven Ove Ögren; H»kan Hall; Christer Köhler; Olle Magnusson; Sven-Erik Sjöstrand 📂 Article 📅 1986 🏛 Springer 🌐 English ⚖ 791 KB

The actions on central dopamine (DA) mechanisms of raclopride, a new substituted benzamide, were studied by means of behavioural and biochemical methods in the rat. Raclopride blocked the in vitro binding of the dopamine D2 antagonist 3H-spiperone (ICso = 32 nM), but not of the unselective D1 antago