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Identification of a Molecular Recognition Role for the Activation Loop Phosphotyrosine of the Src Tyrosine Kinase

✍ Scribed by Videlock, Elizabeth J.; Chung, Victor K.; Hall, Justin M.; Hines, John; Agapakis, Christina M.; Austin, David J.

Book ID: 126206558
Publisher: American Chemical Society
Year: 2005
Tongue: English
Weight: 61 KB
Volume: 127
Category: Article
ISSN: 0002-7863
DOI: 10.1021/ja047957c

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## Abstract Hyperphosphorylation at tyrosine is commonly observed in tumor proteomes and, hence, specific phosphoproteins or phosphopeptides could serve as markers useful for cancer diagnostics and therapeutics. The analysis of such targets is, however, a challenging task, because of their commonly