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In silico activation of Src tyrosine kinase reveals the molecular basis for intramolecular autophosphorylation

✍ Scribed by Jesús Mendieta; Federico Gago

Book ID
108181043
Publisher
Elsevier Science
Year
2004
Tongue
English
Weight
610 KB
Volume
23
Category
Article
ISSN
1093-3263

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✍ Ninad V. Prabhu; Subeeh A. Siddiqui; John S. McMurray; B. Montgomery Pettitt 📂 Article 📅 2001 🏛 Wiley (John Wiley & Sons) 🌐 English ⚖ 444 KB 👁 2 views

Conformational searches on three closely related pp60 c-src protein tyrosine kinase inhibitors of varying potencies were performed to determine a structural basis for their activity. The first was a linear peptide (PDNEYAFFQf), the second its 10-membered cyclic analogue, and the third a cyclic analo