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Identification of 5-meta-Hydroxyphenyl-5-phenylhydantoin as a metabolite of diphenylhydantoin

✍ Scribed by Arthur J. Atkinson Jr.; Joseph MacGee; John Strong; Daniel Garteiz; Thomas E. Gaffney

Book ID
115770559
Publisher
Elsevier Science
Year
1970
Tongue
English
Weight
675 KB
Volume
19
Category
Article
ISSN
0006-2952

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Synthesis of carbon-14 labeled diphenylh
Synthesis of carbon-14 labeled diphenylhydantoin and its major metabolite 5-(p-hydroxyphenyl)-5-phenylhydantoin (HPPH) in 70 minutes
✍ S. Stavchansky; H. B. Kostenbauder πŸ“‚ Article πŸ“… 1974 πŸ› John Wiley and Sons 🌐 French βš– 176 KB

## Abstract A simple and convenient method for the synthesis of carbon‐^14^ labeled diphenylhydantoin (DPH) (I) and its major metabolite 5‐(p‐hydroxyphenyl)‐5‐phenylhydantoin (HPPH) (II) in 70 minutes is described. This synthesis allows incorporation of carbon‐11‐^11^ (physical half‐life 20 minutes