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Absolute configuration of (+)-5-(3-hydroxyphenyl)-5-phenylhydantoin, the major metabolite of 5,5-diphenylhydantoin in the dog

✍ Scribed by Maguire, James H.; Butler, Thomas C.; Dudley, Kenneth H.

Book ID
126330099
Publisher
American Chemical Society
Year
1978
Tongue
English
Weight
610 KB
Volume
21
Category
Article
ISSN
0022-2623

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Synthesis of carbon-14 labeled diphenylh
Synthesis of carbon-14 labeled diphenylhydantoin and its major metabolite 5-(p-hydroxyphenyl)-5-phenylhydantoin (HPPH) in 70 minutes
✍ S. Stavchansky; H. B. Kostenbauder πŸ“‚ Article πŸ“… 1974 πŸ› John Wiley and Sons 🌐 French βš– 176 KB

## Abstract A simple and convenient method for the synthesis of carbon‐^14^ labeled diphenylhydantoin (DPH) (I) and its major metabolite 5‐(p‐hydroxyphenyl)‐5‐phenylhydantoin (HPPH) (II) in 70 minutes is described. This synthesis allows incorporation of carbon‐11‐^11^ (physical half‐life 20 minutes