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Synthesis of carbon-14 labeled diphenylhydantoin and its major metabolite 5-(p-hydroxyphenyl)-5-phenylhydantoin (HPPH) in 70 minutes

✍ Scribed by S. Stavchansky; H. B. Kostenbauder

Publisher: John Wiley and Sons
Year: 1974
Tongue: French
Weight: 176 KB
Volume: 10
Category: Article
ISSN: 0022-2135
DOI: 10.1002/jlcr.2590100314

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✦ Synopsis

Abstract

A simple and convenient method for the synthesis of carbon‐^14^ labeled diphenylhydantoin (DPH) (I) and its major metabolite 5‐(p‐hydroxyphenyl)‐5‐phenylhydantoin (HPPH) (II) in 70 minutes is described. This synthesis allows incorporation of carbon‐11‐^11^ (physical half‐life 20 minutes) into these molecules. Incorporation of short‐lived isotopes into drug molecules provides a vastly expanded potential for study of in vivo distribution of drugs and development of tumor specific agents.

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Effect of 5-(p-hydroxyphenyl)-5-phenylhydantoin (p-HPPH) enantiomers, major metabolites of phenytoin, on the occurrence of chronic-gingival hyperplasia: in vivo and in vitro study

✍ I. Ieiri; W. Goto; S. Higuchi; K. Hirata; A. Toshitani; S. Imayama; Y. Ohyama; H 📂 Article 📅 1995 🏛 Springer 🌐 English ⚖ 571 KB

The purpose of this study was to assess the possible role of the (R)-and (S)-enantiomers of the phenytoin metabolite p-HPPH in the pathogenesis of gingival hyperplasia (GH). About 98% of circulating p-HPPH is in the (S)-form. There were significant differences between patients with and without GH in