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Identification of 5-Keto-(7E,9E,11Z,14Z)-Eicosatetraenoic Acid as a Novel Nonenzymatic Rearrangement Product of Leukotriene A4

โœ Scribed by J. Gravel; J.P. Falgueyret; J. Yergey; L. Trimble; D. Riendeau


Book ID
115564712
Publisher
Elsevier Science
Year
1993
Tongue
English
Weight
575 KB
Volume
306
Category
Article
ISSN
0003-9861

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A stereoselective synthesis of 4, a possible biosynthetic precursor of lipoxins, is reported. A pathway is suggested by which 4 can give rise to the biologically active lipoxins 1 and 2. In 1984 Serhan, Hamberg and Samuelsson reported that human leukocytes convert 15(S)-