✦ LIBER ✦

Identification and Preliminary Characterization of a Potent, Safe, and Orally Efficacious Inhibitor of Acyl-CoA:Diacylglycerol Acyltransferase 1

✍ Scribed by Yeh, Vince S. C.; Beno, David W. A.; Brodjian, Sevan; Brune, Michael E.; Cullen, Steven C.; Dayton, Brian D.; Dhaon, Madhup K.; Falls, Hugh D.; Gao, Ju; Grihalde, Nelson; Hajduk, Philip; Hansen, T. Matthew; Judd, Andrew S.; King, Andrew J.; Klix, Russel C.; Larson, Kelly J.; Lau, Yau Y.; Marsh, Kennan C.; Mittelstadt, Scott W.; Plata, Dan; Rozema, Michael J.; Segreti, Jason A.; Stoner, Eric J.; Voorbach, Martin J.; Wang, Xiaojun; Xin, Xili; Zhao, Gang; Collins, Christine A.; Cox, Bryan F.; Reilly, Regina M.; Kym, Philip R.; Souers, Andrew J.

Book ID: 127119136
Publisher: American Chemical Society
Year: 2012
Tongue: English
Weight: 484 KB
Volume: 55
Category: Article
ISSN: 0022-2623
DOI: 10.1021/jm201524g

No coin nor oath required. For personal study only.

📜 SIMILAR VOLUMES

Discovery of a Potent, Selective, and Or

Discovery of a Potent, Selective, and Orally Efficacious Pyrimidinooxazinyl Bicyclooctaneacetic Acid Diacylglycerol Acyltransferase-1 Inhibitor

✍ Birch, Alan M.; Birtles, Susan; Buckett, Linda K.; Kemmitt, Paul D.; Smith, Grah 📂 Article 📅 2009 🏛 American Chemical Society 🌐 English ⚖ 501 KB

Identification and characterization of a

Identification and characterization of an acyl-CoA:diacylglycerol acyltransferase 2 (DGAT2) gene from the microalga O. tauri

✍ Martin Wagner; Katharina Hoppe; Tibor Czabany; Mareike Heilmann; Günther Daum; I 📂 Article 📅 2010 🏛 Elsevier Science 🌐 English ⚖ 857 KB

Directed evolution of acyl-CoA:diacylgly

Directed evolution of acyl-CoA:diacylglycerol acyltransferase: Development and characterization of Brassica napus DGAT1 mutagenized libraries

✍ Rodrigo M.P. Siloto; Martin Truksa; Disa Brownfield; Allen G. Good; Randall J. W 📂 Article 📅 2009 🏛 Elsevier Science 🌐 English ⚖ 389 KB

Relative and Absolute Stereochemistry of

Relative and Absolute Stereochemistry of Pyripyropene A, A Potent, Bioavailable Inhibitor of Acyl-CoA:Cholesterol Acyltransferase (ACAT)

✍ Tomoda, Hiroshi; Nishida, Hiroyuki; Kim, Young Kook; Obata, Rika; Sunazuka, Tosh 📂 Article 📅 1994 🏛 American Chemical Society 🌐 English ⚖ 234 KB

ChemInform Abstract: Discovery of a Pote

ChemInform Abstract: Discovery of a Potent and Orally Available Acyl-CoA: Cholesterol Acyltransferase Inhibitor as an Antiatherosclerotic Agent: (4-Phenylcoumarin)acetanilide Derivatives.

✍ Masaki Ogino; et al. et al. 📂 Article 📅 2012 🏛 John Wiley and Sons ⚖ 21 KB 👁 1 views

## Abstract Structure‐activity relationship studies lead to the discovery of compound (I), which shows potent ACAT inhibitory activity (IC~50~ = 12 nM) and good pharmacokinetic profile in mice.

ChemInform Abstract: Total Synthesis of

ChemInform Abstract: Total Synthesis of (+)-Pyripyropene A. A Potent, Orally Bioavailable Inhibitor of Acyl-CoA:Cholesterol Acyltransferase.

✍ T. NAGAMITSU; T. SUNAZUKA; R. OBATA; H. TOMODA; H. TANAKA; Y. HARIGAYA; S. OMURA 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 31 KB