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ChemInform Abstract: Total Synthesis of (+)-Pyripyropene A. A Potent, Orally Bioavailable Inhibitor of Acyl-CoA:Cholesterol Acyltransferase.

✍ Scribed by T. NAGAMITSU; T. SUNAZUKA; R. OBATA; H. TOMODA; H. TANAKA; Y. HARIGAYA; S. OMURA; A. B. III. SMITH


Book ID
112031314
Publisher
John Wiley and Sons
Year
2010
Weight
31 KB
Volume
27
Category
Article
ISSN
0931-7597

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## Abstract Structure‐activity relationship studies lead to the discovery of compound (I), which shows potent ACAT inhibitory activity (IC~50~ = 12 nM) and good pharmacokinetic profile in mice.