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Identification and characterization of deoxyguanosine-crotonaldehyde adducts. Formation of 7,8 cyclic adducts and 1,N2,7,8-bis-cyclic adducts

✍ Scribed by Eder, Erwin; Hoffman, Christian


Book ID
126161887
Publisher
American Chemical Society
Year
1992
Tongue
English
Weight
814 KB
Volume
5
Category
Article
ISSN
0893-228X

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Chemical modification of 2 0 -deoxyguanosine and DNA by excessive acetaldehyde and crotonaldehyde were significantly accelerated by the presence of histones, which are nuclear proteins very rich in the basic amino acids such as l-arginine and l-lysine, resulting in the smooth and selective formation