✦ LIBER ✦
Histones accelerate the cyclic 1,N2-propanoguanine adduct-formation of DNA by the primary metabolite of alcohol and carcinogenic crotonaldehyde
✍ Scribed by Magoichi Sako; Shinsuke Inagaki; Yukihiro Esaka; Yoshihiro Deyashiki
- Publisher
- Elsevier Science
- Year
- 2003
- Tongue
- English
- Weight
- 108 KB
- Volume
- 13
- Category
- Article
- ISSN
- 0960-894X
No coin nor oath required. For personal study only.
✦ Synopsis
Chemical modification of 2 0 -deoxyguanosine and DNA by excessive acetaldehyde and crotonaldehyde were significantly accelerated by the presence of histones, which are nuclear proteins very rich in the basic amino acids such as l-arginine and l-lysine, resulting in the smooth and selective formation of the corresponding cyclic 1,N 2 -propanoguanine adducts under physiological conditions. Thus, histones have a very close connection with the genotoxic and carcinogenic effects of these aldehydes.