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( E )-2-Hexenal-Induced DNA Damage and Formation of Cyclic 1, N 2 -(1,3-Propano)-2‘-deoxyguanosine Adducts in Mammalian Cells

✍ Scribed by Gölzer, Petra; Janzowski, Christine; Pool-Zobel, Beatrice L.; Eisenbrand, Gerhard


Book ID
125945178
Publisher
American Chemical Society
Year
1996
Tongue
English
Weight
171 KB
Volume
9
Category
Article
ISSN
0893-228X

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The treatment of guanine nucleosides and nucleotides with excess acetaldehyde in pH 8.0 phosphate buffer containing a basic amino acid such as arginine and lysine resulted in the smooth and selective formation of the corresponding cyclic 1,N 2 -propano adducts even under mild conditions.