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Smooth and selective formation of the cyclic 1,N2-propano adducts in the reactions of guanine nucleosides and nucleotides with acetaldehyde

✍ Scribed by Magoichi Sako; Isamu Yaekura; Yoshihiro Deyashiki

Publisher: Elsevier Science
Year: 2002
Tongue: French
Weight: 71 KB
Volume: 43
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(02)01530-7

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✦ Synopsis

The treatment of guanine nucleosides and nucleotides with excess acetaldehyde in pH 8.0 phosphate buffer containing a basic amino acid such as arginine and lysine resulted in the smooth and selective formation of the corresponding cyclic 1,N 2 -propano adducts even under mild conditions.

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