𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Identification and Characterization of a Deletion Mutant of DNA Topoisomerase I mRNA in a Camptothecin-resistant Subline of Human Colon Carcinoma

✍ Scribed by Yanase, Kae ;Sugimoto, Yoshikazu ;Tsukahara, Satomi ;Oh-hara, Tomoko ;Andoh, Toshiwo ;Tsuruo, Takashi

Book ID
108581918
Publisher
Wiley (Blackwell Publishing)
Year
2000
Tongue
English
Weight
149 KB
Volume
91
Category
Article
ISSN
0910-5050

No coin nor oath required. For personal study only.

πŸ“œ SIMILAR VOLUMES

Retroviral expression of a mutant (GLY-5
Retroviral expression of a mutant (GLY-533) human DNA topoisomerase I cDNA confers a dominant form of camptothecin resistance
✍ Kae Yanase; Yoshikazu Sugimoto; Toshiwo Andoh; Takashi Tsuruo πŸ“‚ Article πŸ“… 1999 πŸ› John Wiley and Sons 🌐 French βš– 188 KB

In previous studies, we isolated a mutant DNA topoisomerase I cDNA from a camptothecin (CPT)-resistant human T-lymphoblastic leukemia cell line, CPT-K5, and demonstrated that an amino acid change from Asp to Gly at residue 533 is responsible for the CPT resistance of the enzyme. In the present study

Quantitative analysis of DNA topoisomera
Quantitative analysis of DNA topoisomerase I activity in human and rat glioma: Characterization and mechanism of resistance to antitopoisomerase chemical, camptothecin-11
✍ Dr. Yoshihito Matsumoto; Takashi Fujiwara; Yasumasa Honjo; Noboru Sasaoka; Takah πŸ“‚ Article πŸ“… 1993 πŸ› John Wiley and Sons 🌐 English βš– 664 KB

Camptothecin-1 1 (CPT-11) is a new derivative of camptothecin, a plant alkaloid antitumor agent. Previous studies indicated that antitumor activity of CPT-11 was mediated through interaction of the drugs with its target enzyme, DNA topoisomerase I (topo I). In this study, we studied the relation bet