𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Characterization of a Mammalian Mutant with a Camptothecin-Resistant DNA Topoisomerase I

✍ Scribed by Toshiwo Andoh, Kazuyuki Ishii, Yoshinobu Suzuki, Yoji Ikegami, Yoichiro Kusunoki, Yumi Takemoto and Kosuke Okada


Book ID
123634563
Publisher
National Academy of Sciences
Year
1987
Tongue
English
Weight
995 KB
Volume
84
Category
Article
ISSN
0027-8424

No coin nor oath required. For personal study only.


πŸ“œ SIMILAR VOLUMES


Retroviral expression of a mutant (GLY-5
✍ Kae Yanase; Yoshikazu Sugimoto; Toshiwo Andoh; Takashi Tsuruo πŸ“‚ Article πŸ“… 1999 πŸ› John Wiley and Sons 🌐 French βš– 188 KB

In previous studies, we isolated a mutant DNA topoisomerase I cDNA from a camptothecin (CPT)-resistant human T-lymphoblastic leukemia cell line, CPT-K5, and demonstrated that an amino acid change from Asp to Gly at residue 533 is responsible for the CPT resistance of the enzyme. In the present study

Quantitative analysis of DNA topoisomera
✍ Dr. Yoshihito Matsumoto; Takashi Fujiwara; Yasumasa Honjo; Noboru Sasaoka; Takah πŸ“‚ Article πŸ“… 1993 πŸ› John Wiley and Sons 🌐 English βš– 664 KB

Camptothecin-1 1 (CPT-11) is a new derivative of camptothecin, a plant alkaloid antitumor agent. Previous studies indicated that antitumor activity of CPT-11 was mediated through interaction of the drugs with its target enzyme, DNA topoisomerase I (topo I). In this study, we studied the relation bet