Characterization of a Mammalian Mutant with a Camptothecin-Resistant DNA Topoisomerase I
β Scribed by Toshiwo Andoh, Kazuyuki Ishii, Yoshinobu Suzuki, Yoji Ikegami, Yoichiro Kusunoki, Yumi Takemoto and Kosuke Okada
- Book ID
- 123634563
- Publisher
- National Academy of Sciences
- Year
- 1987
- Tongue
- English
- Weight
- 995 KB
- Volume
- 84
- Category
- Article
- ISSN
- 0027-8424
- DOI
- 10.2307/30080
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
In previous studies, we isolated a mutant DNA topoisomerase I cDNA from a camptothecin (CPT)-resistant human T-lymphoblastic leukemia cell line, CPT-K5, and demonstrated that an amino acid change from Asp to Gly at residue 533 is responsible for the CPT resistance of the enzyme. In the present study
Camptothecin-1 1 (CPT-11) is a new derivative of camptothecin, a plant alkaloid antitumor agent. Previous studies indicated that antitumor activity of CPT-11 was mediated through interaction of the drugs with its target enzyme, DNA topoisomerase I (topo I). In this study, we studied the relation bet