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Icariin-Mediated Inhibition of NF-κB Activity Enhances the In Vitro and In Vivo Antitumour Effect of 5-Fluorouracil in Colorectal Cancer

✍ Scribed by Shi, De-Bing; Li, Xin-Xiang; Zheng, Hong-Tu; Li, Da-Wei; Cai, Guo-Xiang; Peng, Jun-Jie; Gu, Wei-Lie; Guan, Zu-Qing; Xu, Ye; Cai, San-Jun


Book ID
121570862
Publisher
Springer-Verlag
Year
2014
Tongue
English
Weight
492 KB
Volume
69
Category
Article
ISSN
1085-9195

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## Abstract 5‐Fluorouracil (5‐FU) is the major chemotherapeutic component for colorectal cancer (CRC) and other types of solid tumours. Resistance of cancer cells to 5‐FU is considered the major obstacle for successful chemotherapy. NF‐κB is a transcription factor. Cancer cells with high NF‐κB nucl