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Inhibition of inducible NF-κB activity reduces chemoresistance to 5-fluorouracil in human stomach cancer cell line

✍ Scribed by Hirokazu Uetsuka; Minoru Haisa; Masashi Kimura; Mehmet Gunduz; Yasufumi Kaneda; Takaomi Ohkawa; Munenori Takaoka; Toshihiro Murata; Tetsuji Nobuhisa; Tomoki Yamatsuji; Junji Matsuoka; Noriaki Tanaka; Yoshio Naomoto


Book ID
117099900
Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
418 KB
Volume
289
Category
Article
ISSN
0014-4827

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## Abstract 5‐Fluorouracil (5‐FU) is the major chemotherapeutic component for colorectal cancer (CRC) and other types of solid tumours. Resistance of cancer cells to 5‐FU is considered the major obstacle for successful chemotherapy. NF‐κB is a transcription factor. Cancer cells with high NF‐κB nucl