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5-Fluorouracil Suppression of NF-κB Is Mediated by the Inhibition of IκB Kinase Activity in Human Salivary Gland Cancer Cells

✍ Scribed by Masayuki Azuma; Tsuyoshi Yamashita; Keiko Aota; Tetsuya Tamatani; Mitsunobu Sato

Book ID
115587652
Publisher
Elsevier Science
Year
2001
Tongue
English
Weight
128 KB
Volume
282
Category
Article
ISSN
0006-291X

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## Abstract 5‐Fluorouracil (5‐FU) is the major chemotherapeutic component for colorectal cancer (CRC) and other types of solid tumours. Resistance of cancer cells to 5‐FU is considered the major obstacle for successful chemotherapy. NF‐κB is a transcription factor. Cancer cells with high NF‐κB nucl