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i(12P) negative germ cell tumors: A different group?

✍ Scribed by S. Castedo; R. Seruca; J.W. Oosterhuis; A. Dam; B. de Jong


Book ID
119104460
Publisher
Elsevier Science
Year
1989
Tongue
English
Weight
92 KB
Volume
38
Category
Article
ISSN
0165-4608

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The i( I2p) chromosome has been shown to characterize more than 80% of male germ cell tumors (GCTs) and is an important diagnostic marker. Although recent cytogenetic analyses of GCTs have defined nonrandom chromosome abnormalities in these tumors, no attempt has so far been made to compare i( I2p)-

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## Abstract We present molecular data to demonstrate that the isochromosome 12p, specific for human germ cell tumors (GCTs), is of uniparental origin. Eight GCT‐derived cell lines, containing one or more copies of i(12p) and/or other 12p anomalies, were analyzed with different 12p‐derived polymorph

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