i(12P) negative germ cell tumors: A different group?
β Scribed by S. Castedo; R. Seruca; J.W. Oosterhuis; A. Dam; B. de Jong
- Book ID
- 119104460
- Publisher
- Elsevier Science
- Year
- 1989
- Tongue
- English
- Weight
- 92 KB
- Volume
- 38
- Category
- Article
- ISSN
- 0165-4608
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The i( I2p) chromosome has been shown to characterize more than 80% of male germ cell tumors (GCTs) and is an important diagnostic marker. Although recent cytogenetic analyses of GCTs have defined nonrandom chromosome abnormalities in these tumors, no attempt has so far been made to compare i( I2p)-
## Abstract We present molecular data to demonstrate that the isochromosome 12p, specific for human germ cell tumors (GCTs), is of uniparental origin. Eight GCTβderived cell lines, containing one or more copies of i(12p) and/or other 12p anomalies, were analyzed with different 12pβderived polymorph
## Abstract A chromosome 12βderived marker was seen in each of 3 testicular germ cell tumors that lacked the i(12p). An interesting feature of 2 of the markers was that the major part, including the centromere, of an acrocentric (a #13 and #14, respectively) was translocated onto 12p, resulting in