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Chromosome 12-containing markers, including two dicentrics, in three i(12p)-negative testicular germ cell tumors

✍ Scribed by Niels B. Atkin; Margaret F. Fox; Marion C. Baker; Zoè Jackson

Publisher: John Wiley and Sons
Year: 1993
Tongue: English
Weight: 289 KB
Volume: 6
Category: Article
ISSN: 1045-2257
DOI: 10.1002/gcc.2870060405

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✦ Synopsis

Abstract

A chromosome 12‐derived marker was seen in each of 3 testicular germ cell tumors that lacked the i(12p). An interesting feature of 2 of the markers was that the major part, including the centromere, of an acrocentric (a #13 and #14, respectively) was translocated onto 12p, resulting in a dicentric. In the third tumor, 13q (translocated onto 12q) was again probably involved in the rearrangement. The findings support the view that the amplification of genes on 12p represents a significant step in the development of germ cell tumors. © 1993 Wiley‐Liss, Inc.

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