Hypoxia Modulates Cyclic AMP Activation of BKCaChannels in Rat Pulmonary Arterial Smooth Muscle
โ Scribed by Scott A. Barman; Shu Zhu; Richard E. White
- Publisher
- Springer
- Year
- 2005
- Tongue
- English
- Weight
- 145 KB
- Volume
- 183
- Category
- Article
- ISSN
- 0341-2040
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The effect of dibutyryl cyclic AMP on DNA synthesis was studied in cultured human umbilical endothelial cells and rat aortic smooth muscle cells. Dibutyryl cyclic AMP (2 X 10(-4) mol/l) inhibited DNA synthesis in both arterial cell types when they were grown in medium supplemented with whole serum o
In the rat isolated main pulmonary artery, we investigated the effect of a tyrosine kinase inhibitor (genistein) and that of a tyrosine phosphatase inhibitor (phenylarsine oxide) on agonist-induced contraction. Genistein (10 microM) reduced the amplitude of the contraction evoked by noradrenaline (0