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Effect of PKC Isozyme Inhibition on Forskolin-Induced Activation of BKCaChannels in Rat Pulmonary Arterial Smooth Muscle

โœ Scribed by Shu Zhu; Richard E. White; Scott A. Barman


Publisher
Springer
Year
2006
Tongue
English
Weight
341 KB
Volume
184
Category
Article
ISSN
0341-2040

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โœ J.P. Savineau; P. Gonzalez De La Fuente; R. Marthan ๐Ÿ“‚ Article ๐Ÿ“… 1996 ๐Ÿ› Elsevier ๐ŸŒ English โš– 155 KB

In the rat isolated main pulmonary artery, we investigated the effect of a tyrosine kinase inhibitor (genistein) and that of a tyrosine phosphatase inhibitor (phenylarsine oxide) on agonist-induced contraction. Genistein (10 microM) reduced the amplitude of the contraction evoked by noradrenaline (0