Protein Kinase C Modulation of Cyclic GMP in Rat Neonatal Pulmonary Vascular Smooth Muscle
โ Scribed by J. A. Johnson; S. A. Barman
- Publisher
- Springer
- Year
- 2004
- Tongue
- English
- Weight
- 172 KB
- Volume
- 182
- Category
- Article
- ISSN
- 0341-2040
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๐ SIMILAR VOLUMES
In the rat isolated main pulmonary artery, we investigated the effect of a tyrosine kinase inhibitor (genistein) and that of a tyrosine phosphatase inhibitor (phenylarsine oxide) on agonist-induced contraction. Genistein (10 microM) reduced the amplitude of the contraction evoked by noradrenaline (0
Protein kinase C and mitogen-activated protein (MAP) kinase are expressed in all smooth muscle cells and believed to be important in several physiologically relevant properties of this muscle. Our goal was to determine if protein kinase C and MAP kinase are activated by a simple increase in cellular