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Hypoxia-Inducible Factor-1α and its Role in the Proliferation of Retinoblastoma Cells

✍ Scribed by Fernandes, Bruno F.; Coates, James; Odashiro, Alexandre N.; Quezada, Carlos; Huynh, Aimee; Odashiro, Patricia R.; Odashiro, Macanori; Burnier, Miguel N.

Book ID: 121591171
Publisher: Springer Netherlands
Year: 2013
Tongue: English
Weight: 334 KB
Volume: 20
Category: Article
ISSN: 1219-4956
DOI: 10.1007/s12253-013-9728-8

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## Abstract Dendritic cells (DC) are the most potent antigen‐presenting cells and during their life cycle they are exposed to different oxygen tensions. Similarly to inflamed and tumor tissues, lymphoid organs are characterized by a hypoxic microenvironment; thus, the modality by which hypoxia may