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Hypoxia decreased chemosensitivity of breast cancer cell line MCF-7 to paclitaxel through cyclin B1

✍ Scribed by X.L. Dong; P.F. Xu; C. Miao; Z.Y. Fu; Q.P. Li; P.Y. Tang; T. Wang


Book ID
116314436
Publisher
Elsevier Science
Year
2012
Tongue
English
Weight
895 KB
Volume
66
Category
Article
ISSN
0753-3322

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## Abstract Paclitaxel (PTX) is a very effective drug in treating tumors. It disturbs microtubule dynamics and impairs the transition of cells from metaphase to anaphase in mitosis, leading to cell death by apoptosis. However, the effectiveness of PTX in cancer chemotherapy is hampered by drug resi