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TIMP-1 protects MCF-7 breast cancer cells from paclitaxel-induced apoptosis by decreasing the stability of cyclin B1

โœ Scribed by Ting Wang; Jing-Huan Lv; Xiong-Fei Zhang; Chao-Jun Li; Xiao Han; Yu-Jie Sun


Book ID
116314184
Publisher
Elsevier Science
Year
2009
Tongue
English
Weight
37 KB
Volume
63
Category
Article
ISSN
0753-3322

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## Abstract Paclitaxel (PTX) is a very effective drug in treating tumors. It disturbs microtubule dynamics and impairs the transition of cells from metaphase to anaphase in mitosis, leading to cell death by apoptosis. However, the effectiveness of PTX in cancer chemotherapy is hampered by drug resi