Hypoxia attenuates the p53 response to cellular damage
β Scribed by Achison, Marcus; Hupp, Ted R
- Book ID
- 110067541
- Publisher
- Nature Publishing Group
- Year
- 2003
- Tongue
- English
- Weight
- 352 KB
- Volume
- 22
- Category
- Article
- ISSN
- 0950-9232
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π SIMILAR VOLUMES
Exposure of mammalian cells to genotoxic agents evokes a complex cellular response. An ordered series of molecular events is necessary to sense DNA damage, transduce the signal, and ultimately delay the cell cycle or trigger apoptosis. Recently, we have shown that BTG2/TIS21 gene expression was indu
## Abstract The tumor suppressor p53 plays a central role in the DNA damage response. After exposure to genotoxic stress, p53 can both positively and negatively regulate cell fate. Initially, p53 promotes cell survival by inducing cell cycle arrest, DNA repair, and other proβsurvival pathways. Howe