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Hypolipidemic activity of trimethylamine-carbomethoxyborane and related derivatives in rodents

โœ Scribed by Iris H. Hall; Bernard F. Spielvogel; Anup Sood; Fahim Ahmed; Samir Jafri

Publisher
John Wiley and Sons
Year
1987
Tongue
English
Weight
756 KB
Volume
76
Category
Article
ISSN
0022-3549

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A series of substituted 2-pyrrolidinones was evaluated for hypolipidemic activity a t 20 and 30 mg/kg/day in CF1 male mice. 4-Phenyl-5,5-dicarbethoxy-2-pyrrolidinone was the most potent compound a t 30 mg/kg/day, reducing serum triglyceride levels 52% after 14 days of dosing and serum cholesterol le