Hypolipidemic activity of substituted 2-pyrrolidinones in rodents

✍ Scribed by George H. Cocolas; James M. Chapman Jr.; P. Josée Voorstad; Iris H. Hall

• Publisher: John Wiley and Sons
• Year: 1983
• Tongue: English
• Weight: 329 KB
• Volume: 72
• Category: Article
• ISSN: 0022-3549
• DOI: 10.1002/jps.2600720723

✦ Synopsis

A series of substituted 2-pyrrolidinones was evaluated for hypolipidemic activity a t 20 and 30 mg/kg/day in CF1 male mice. 4-Phenyl-5,5-dicarbethoxy-2-pyrrolidinone was the most potent compound a t 30 mg/kg/day, reducing serum triglyceride levels 52% after 14 days of dosing and serum cholesterol levels 48% after 16 days of dosing. 4-Phenyl-5-carbethoxy-2-pyrrolidinone and 4-phenyl-3,5,5-tricarbethoxy-2-pyrrolidinone also demonstrated significant activity. Those compounds which contained a phenyl substituent were more potent than either the unsubstituted, the alkyl, or the dicarbethoxy 2-pyrrolidinone analogues.

Keyphrases 0 2-Pyrrolidinones-synthesis of substituted analogues, hypolipidemic activity in mice 0 Antihyperlipidemic agentssubstituted 2-pyrrolidinone analogues, synthesis, hypolipidemic activity in mice Succinimide-2-pyrrolidinone congeners, synthesis of substituted analogues, hypolipidemic activity in mice ' Fisher, Hycel Triglyceride Test (1975). Hycel. Inc.