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Hypolipidemic activity of 4-phenyl-5,5-dicarbethoxy-2-pyrrolidinone in rodents

โœ Scribed by I. H. Hall; G. H. Cocolas; P. J. Voorstad

Publisher
John Wiley and Sons
Year
1984
Tongue
English
Weight
439 KB
Volume
73
Category
Article
ISSN
0022-3549

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๐Ÿ“œ SIMILAR VOLUMES

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โœ George H. Cocolas; James M. Chapman Jr.; P. Josรฉe Voorstad; Iris H. Hall ๐Ÿ“‚ Article ๐Ÿ“… 1983 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 329 KB

A series of substituted 2-pyrrolidinones was evaluated for hypolipidemic activity a t 20 and 30 mg/kg/day in CF1 male mice. 4-Phenyl-5,5-dicarbethoxy-2-pyrrolidinone was the most potent compound a t 30 mg/kg/day, reducing serum triglyceride levels 52% after 14 days of dosing and serum cholesterol le

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