Hypoglycemic and uricosuric properties of acetohexamide and hydroxyhexamide
β Scribed by Ts'ai-fan Yu; Lawrence Berger; Alexander B. Gutman
- Book ID
- 118946689
- Publisher
- Elsevier Science
- Year
- 1968
- Tongue
- English
- Weight
- 599 KB
- Volume
- 17
- Category
- Article
- ISSN
- 1532-8600
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π SIMILAR VOLUMES
A sensitive and specific GLC assay was developed for acetohexamide and hydroxyhexamide, its major metabolite, in plasma and urine. The assay uses tolbutamide as a mass internal standard. Compounds are extracted from acidified plasma or urine with toluene, converted to methylated derivatives with dim
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Analogs submitted by ethyl, \(n\)-propyl, \(n\)-butyl, and isopropyl groups instead of methyl group adjacent to a ketone group of acetohexamide were synthesized and the structural requirements of carbonyl reductase from rabbit kidney for these analogs were kinetically examined. The hydrophobicities