Six children received etoposide as the single agent for treatment of Langerhans cell histiocytosis (LCH; histiocytosis X). Five were less than 2 years old at diagnosis. All had multiorgan involvement; one had liver and pulmonary dysfunction. Two infants also had clinical signs of immune deficiency.
Hypofibrinogenemia in a girl with Langerhans cell histiocytosis during etoposide and prednisolone therapy
β Scribed by TAKUMA MIURA; MITSURU NAKAMURA; YUKIKO TSUNEMATSU; JUNICHIRO FUJIMOTO; TAKASHI MEGURO; KANEO YAMADA
- Book ID
- 118711849
- Publisher
- John Wiley and Sons
- Year
- 1993
- Tongue
- English
- Weight
- 390 KB
- Volume
- 35
- Category
- Article
- ISSN
- 1328-8067
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Viana et al. [I] described their experience with etoposide (VP-16) as initial therapy in the management of patients with Langerhans cell histiocytosis (LCH). However, caution should be used in advocating the use of an epipodophyllotoxin as the "drug of choice" for the treatment of this disorder. Alt
## Abstract An international randomized trial in Langerhans cell histiocytosis (LCH) has been initiated by the Histiocyte Society. This report reviews the rationale, design, and progress of LCHβI, which compares etoposide (VPβ16) and vinblastine in the treatment of disseminated LCH. Data on the ris