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LCH-I: A randomized trial of etoposide vs. vinblastine in disseminated langerhans cell histiocytosis

✍ Scribed by Ladisch, Stephan ;Gadner, Helmut ;Arico, Maurizio ;Broadbent, Valerie ;Grois, Nicole ;Jacobson, Ake ;Komp, Diane ;Nicholson, H. Stacy

Publisher: John Wiley and Sons
Year: 1994
Tongue: English
Weight: 403 KB
Volume: 23
Category: Article
ISSN: 0098-1532
DOI: 10.1002/mpo.2950230207

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

An international randomized trial in Langerhans cell histiocytosis (LCH) has been initiated by the Histiocyte Society. This report reviews the rationale, design, and progress of LCH‐I, which compares etoposide (VP‐16) and vinblastine in the treatment of disseminated LCH. Data on the risk of etoposide‐associated (therapy‐induced) malignancy, in the setting of histiocytosis, are reviewed. The available evidence leads to the recommendation that the study of etoposide in LCH should be continued. © 1994 Wiley‐Liss, Inc.

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